Cellular response to sodium arsenite

Across TCGA cell cohorts, RNA activity of the Cellular response to sodium arsenite pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP39, SCRIB, and HSF1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to sodium arsenite activity versus ARHGAP39 in BONE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARHGAP39 →	+1.077	+0.165	.009	<.001	3	14
BLOOD_Lymphoma	SCRIB →	+0.989	+0.098	<.001	<.001	3	12
BONE	HSF1 →	+1.041	+0.214	.001	<.001	3	12
BLOOD_Lymphoma	BOP1 →	+1.007	+0.089	.001	.006	3	12
LIVER	SHARPIN →	+0.596	+0.145	.002	.008	3	11
LUNG_SCLC	MAPK13 →	+2.560	+0.141	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903936 vs ARHGAP39 — BONE

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