Cellular response to sodium arsenite

Across TCGA cell cohorts, RNA activity of the Cellular response to sodium arsenite pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM69, ARPC2, and NAPRT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to sodium arsenite activity versus TMEM69 in SKIN (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM69 →	+0.483	+0.145	.001	.006	3	4
LUNG_NSCLC_LUSC	ARPC2 →	-1.644	-0.252	<.001	.005	3	4
BLOOD_Myeloma	NAPRT →	-2.366	-0.187	.003	.003	3	4
BLOOD_Leukemia	ESPN →	-1.278	-0.118	.003	.001	3	4
LUNG_NSCLC_LUAD	ELMO3 →	-1.848	-0.169	.002	.001	3	4
LUNG_NSCLC_LUAD	IRF7 →	-1.520	-0.144	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903936 vs TMEM69 — SKIN

Explore this scatter interactively →