Response to sodium arsenite

Across TCGA patient cohorts, RNA activity of the Response to sodium arsenite pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYBA, HK3, and ITGAM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sodium arsenite activity versus CYBA in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYBA →	+0.470	+0.072	.002	.003	3	6
GBM	HK3 →	+0.897	+0.078	<.001	.004	3	6
GBM	ITGAM →	+0.836	+0.093	<.001	<.001	3	6
BRCA	NCF4 →	+0.462	+0.075	<.001	.002	3	6
OV	APOBR →	+0.549	+0.098	<.001	<.001	3	6
CCRCC	AMPD3 →	+0.234	+0.056	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903935 vs CYBA — LSCC

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