Response to sodium arsenite

Across TCGA patient cohorts, RNA activity of the Response to sodium arsenite pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRTM3, CD22, and ZNF296, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sodium arsenite activity versus LRRTM3 in LSCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LRRTM3 →	+0.297	+0.209	.002	.007	3	4
GBM	CD22 →	+1.489	+0.860	<.001	<.001	3	3
HNSC	ZNF296 →	+0.350	+0.650	.008	<.001	3	3
PDAC	RBBP4P4 →	+0.368	+0.464	.002	.005	3	3
GBM	FAM78A →	+0.448	+0.497	<.001	.001	3	3
GBM	ABCA8 →	+1.204	+0.764	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903935 vs LRRTM3 — LSCC

Explore this scatter interactively →