Response to sodium arsenite

Across TCGA cell cohorts, RNA activity of the Response to sodium arsenite pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRL3, NCS1, and ZCCHC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADGRL3 grouped by Response to sodium arsenite-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ADGRL3 →	-0.254	-0.161	.002	.005	3	5
OVARY	NCS1 →	-0.142	-0.094	.003	.004	3	4
OESOPHAGUS	ZCCHC3 →	-0.152	-0.152	.005	.002	3	4
LARGE_INTESTINE	E2F8 →	-0.139	-0.093	<.001	.001	3	4
LUNG_NSCLC_LUSC	FBXO9 →	-0.339	-0.160	.001	.002	3	4
KIDNEY	FCN2 →	-0.221	-0.150	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADGRL3 by Response to sodium arsenite activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →