Response to sodium arsenite

Across TCGA cell cohorts, RNA activity of the Response to sodium arsenite pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL32, NAPRT, and NUDT22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sodium arsenite activity versus MRPL32 in OESOPHAGUS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MRPL32 →	-0.823	-0.165	<.001	.008	3	5
BLOOD_Myeloma	NAPRT →	-2.391	-0.211	.003	.001	3	4
KIDNEY	NUDT22 →	-0.937	-0.297	.007	.005	3	4
URINARY_TRACT	DNAJB9 →	+1.142	+0.235	.001	.004	3	4
URINARY_TRACT	ABCA1 →	+2.700	+0.206	<.001	<.001	3	4
STOMACH	PPP1R16A →	-0.802	-0.143	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903935 vs MRPL32 — OESOPHAGUS

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