Regulation of receptor clustering

Across TCGA patient cohorts, RNA activity of the Regulation of receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSPP1, E2F5, and DDAH1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor clustering activity versus CSPP1 in GBM (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSPP1 →	-0.406	-0.324	<.001	.007	3	3
LUAD	E2F5 →	-0.521	-0.758	.001	.001	3	3
GBM	DDAH1 →	-0.712	-0.402	.001	.007	3	3
GBM	NDUFA3P1 →	-0.467	-0.342	<.001	.006	3	3
BRCA	LMOD1 →	+0.874	+0.429	.002	.003	3	3
BRCA	FILIP1L →	+0.767	+0.344	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903909 vs CSPP1 — GBM

Explore this scatter interactively →