Regulation of receptor clustering

Across TCGA cell cohorts, RNA activity of the Regulation of receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNS3, GDPD3, and NFIA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNS3 grouped by Regulation of receptor clustering-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KCNS3 →	+1.607	+1.035	.001	<.001	3	4
LUNG_NSCLC_LUAD	GDPD3 →	+1.626	+0.802	<.001	.003	3	4
LUNG_NSCLC_LUAD	NFIA →	+0.789	+1.038	.003	.001	3	4
CNS	AGBL5 →	+0.473	+0.952	.002	<.001	3	4
BLOOD_Leukemia	GNMT →	+0.418	+1.135	.002	<.001	2	5
OESOPHAGUS	ADGRV1 →	+2.122	+1.195	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNS3 by Regulation of receptor clustering activity — BREAST

Explore this box plot interactively →