Regulation of establishment of T cell polarity

Across TCGA patient cohorts, RNA activity of the Regulation of establishment of T cell polarity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN6, SPN, and FES, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of T cell polarity activity versus SEPTIN6 in LSCC (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SEPTIN6 →	+0.566	+0.124	<.001	<.001	3	9
GBM	SPN →	+0.609	+0.082	<.001	<.001	3	9
LSCC	FES →	+0.366	+0.096	<.001	<.001	3	9
LSCC	ARHGDIB →	+0.687	+0.119	<.001	<.001	3	9
LSCC	RCSD1 →	+0.620	+0.111	<.001	<.001	3	8
UCEC	RENBP →	+0.500	+0.059	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903903 vs SEPTIN6 — LSCC

Explore this scatter interactively →