Regulation of establishment of T cell polarity

Across TCGA patient cohorts, RNA activity of the Regulation of establishment of T cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL10RA, DOCK10, and GPR174, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of T cell polarity activity versus IL10RA in LSCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL10RA →	+0.929	+0.685	<.001	.003	3	7
UCEC	DOCK10 →	+0.650	+0.450	.003	.007	3	7
LSCC	GPR174 →	+1.144	+0.851	<.001	<.001	3	7
LSCC	LILRB1 →	+0.725	+0.619	<.001	.009	3	7
LSCC	BTK →	+0.571	+0.741	<.001	<.001	3	6
UCEC	BIN2 →	+0.657	+0.432	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903903 vs IL10RA — LSCC

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