Regulation of establishment of T cell polarity

Across TCGA patient cohorts, RNA activity of the Regulation of establishment of T cell polarity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3_S38, VAV1, and WDFY4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of T cell polarity activity versus SASH3_S38 in LSCC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SASH3_S38 →	+1.013	+0.676	<.001	<.001	3	6
LSCC	VAV1 →	+0.617	+1.048	<.001	<.001	3	6
LSCC	WDFY4 →	+0.613	+0.981	<.001	<.001	3	6
UCEC	BIN2 →	+0.742	+0.622	<.001	<.001	3	6
LSCC	DOCK10 →	+0.534	+0.841	<.001	<.001	3	6
LSCC	DOCK2_S1685 →	+0.702	+0.787	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903903 vs SASH3_S38 — LSCC

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