Regulation of establishment of T cell polarity

Across TCGA cell cohorts, RNA activity of the Regulation of establishment of T cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPD, TENT5A, and MAPKAPK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of T cell polarity activity versus CPD in BLOOD_Lymphoma (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CPD →	+2.013	+0.978	<.001	.001	3	3
BLOOD_Leukemia	TENT5A →	+2.476	+0.688	.001	.006	3	3
BLOOD_Lymphoma	MAPKAPK3 →	+1.318	+1.086	<.001	.002	3	3
BLOOD_Myeloma	RPL5 →	-0.759	-1.351	.006	.005	3	3
BLOOD_Myeloma	TRIM21 →	+1.319	+1.973	<.001	<.001	3	3
BLOOD_Myeloma	ATP6V1B2 →	+1.188	+1.649	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903903 vs CPD — BLOOD_Lymphoma

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