Positive regulation of viral life cycle

Across TCGA patient cohorts, RNA activity of the Positive regulation of viral life cycle pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LGALS9, TRIM21, and CMPK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of viral life cycle activity versus LGALS9 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LGALS9 →	+0.585	+0.042	<.001	<.001	3	9
GBM	TRIM21 →	+0.454	+0.049	<.001	<.001	3	8
HNSC	CMPK2 →	+0.680	+0.054	<.001	.001	3	8
OV	MX2 →	+0.694	+0.060	<.001	<.001	3	8
GBM	LPXN →	+0.518	+0.045	.004	.005	3	8
BRCA	ADA2 →	+0.442	+0.045	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903902 vs LGALS9 — GBM

Explore this scatter interactively →