Positive regulation of viral life cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of viral life cycle pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCEH1, HSPA1L, and IL10RB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCEH1 grouped by Positive regulation of viral life cycle-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NCEH1 →	+1.569	+0.468	.003	.001	3	4
LARGE_INTESTINE	HSPA1L →	+0.334	+0.473	<.001	.003	3	3
LARGE_INTESTINE	IL10RB →	+0.699	+0.433	<.001	.007	3	3
BLOOD_Lymphoma	MLH1 →	+0.600	+0.192	.001	.003	3	3
CNS	C7orf61 →	-0.480	-0.826	<.001	.004	3	3
BREAST	RAC1 →	+0.478	+0.275	.004	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCEH1 by Positive regulation of viral life cycle activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →