Positive regulation of viral life cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of viral life cycle pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPINT1, LGALS1, and RFT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of viral life cycle activity versus SPINT1 in URINARY_TRACT (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SPINT1 →	-4.209	-0.291	.004	.006	3	8
BLOOD_Leukemia	LGALS1 →	+4.086	+0.191	<.001	<.001	3	7
BLOOD_Leukemia	RFT1 →	+0.561	+0.150	.002	.005	3	7
BREAST	FOSL1 →	+3.170	+0.203	<.001	.001	3	7
URINARY_TRACT	FA2H →	-2.105	-0.464	.001	<.001	3	7
KIDNEY	DBF4B →	+1.102	+0.205	.004	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903902 vs SPINT1 — URINARY_TRACT

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