Positive regulation of viral life cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of viral life cycle pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KPNA2, KPNA7, and RPS14, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of viral life cycle activity versus KPNA2 in PANCREAS (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KPNA2 →	+1.715	+0.320	<.001	<.001	3	17
PANCREAS	KPNA7 →	+1.700	+0.337	<.001	<.001	3	13
PANCREAS	RPS14 →	+1.123	+0.335	.001	.001	3	11
PANCREAS	RPL12 →	+0.692	+0.286	<.001	<.001	3	11
PANCREAS	RPL23A →	+0.748	+0.333	<.001	.001	3	11
OVARY	CSDE1 →	+1.502	+0.173	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903902 vs KPNA2 — PANCREAS

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