Negative regulation of viral life cycle

Across TCGA patient cohorts, RNA activity of the Negative regulation of viral life cycle pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP6, TBC1D30, and TGFB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral life cycle activity versus TNFAIP6 in LSCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNFAIP6 →	+0.933	+0.166	.002	.005	3	5
HNSC	TBC1D30 →	-0.378	-0.154	.001	.005	3	5
LSCC	TGFB3 →	+0.428	+0.117	.005	.001	3	4
COAD	LOXL1 →	+0.783	+0.215	.002	<.001	3	4
LSCC	MICAL2 →	+0.671	+0.183	.003	<.001	3	4
LSCC	ANGPTL2 →	+0.940	+0.236	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903901 vs TNFAIP6 — LSCC

Explore this scatter interactively →