Negative regulation of viral life cycle

Across TCGA cell cohorts, RNA activity of the Negative regulation of viral life cycle pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSL3, TPST2, and TYW5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSL3 grouped by Negative regulation of viral life cycle-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MSL3 →	-0.818	-0.413	.002	.002	3	4
CNS	TPST2 →	-0.836	-0.740	.008	.005	3	4
STOMACH	TYW5 →	+0.597	+1.434	<.001	.005	3	3
BLOOD_Lymphoma	GINM1 →	-0.944	-1.750	.004	.005	2	4
SOFT_TISSUE	SRSF8 →	+0.791	+0.964	<.001	.008	3	3
SOFT_TISSUE	RNF115 →	+0.551	+0.964	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSL3 by Negative regulation of viral life cycle activity — PANCREAS

Explore this box plot interactively →