Negative regulation of viral life cycle

Across TCGA cell cohorts, RNA activity of the Negative regulation of viral life cycle pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BST2, CCDC194, and RAB42, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of viral life cycle activity versus BST2 in LARGE_INTESTINE (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BST2 →	+4.366	+0.152	<.001	<.001	3	11
OVARY	CCDC194 →	+0.782	+0.165	<.001	.001	2	12
KIDNEY	RAB42 →	+2.947	+0.171	<.001	<.001	3	5
OVARY	NNT →	+0.926	+0.114	.007	.007	3	5
BLOOD_Lymphoma	BATF3 →	+3.707	+0.082	<.001	.002	3	5
OVARY	IL32 →	+3.274	+0.137	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903901 vs BST2 — LARGE_INTESTINE

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