Negative regulation of PERK-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the Negative regulation of PERK-mediated unfolded protein response pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCK1, NCK2, and MSN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of PERK-mediated unfolded protein response activity versus NCK1 in LSCC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NCK1 →	+0.276	+0.058	<.001	<.001	3	8
COAD	NCK2 →	+0.128	+0.021	.007	.004	3	5
PDAC	MSN →	+0.304	+0.045	<.001	.003	3	5
GBM	PPM1F →	+0.200	+0.033	<.001	.003	3	5
LUAD	DENND2B →	+0.270	+0.066	<.001	<.001	3	5
COAD	RSBN1_S81 →	-0.299	-0.026	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903898 vs NCK1 — LSCC

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