Negative regulation of PERK-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the Negative regulation of PERK-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VILL, OR7E162P, and MEIS1-AS3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of PERK-mediated unfolded protein response activity versus VILL in BRCA (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VILL →	-0.504	-0.470	.004	.003	3	3
GBM	OR7E162P →	-0.086	-0.702	.003	<.001	3	3
CCRCC	MEIS1-AS3 →	-0.238	-0.520	<.001	.003	3	3
BRCA	ZDHHC3 →	-0.436	-0.574	<.001	.001	3	3
BRCA	LINC00449 →	-0.217	-0.420	.001	.008	3	3
BRCA	OSBPL5 →	-0.655	-0.551	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903898 vs VILL — BRCA

Explore this scatter interactively →