Negative regulation of PERK-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Negative regulation of PERK-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, PTPN1, and CHMP4B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of PERK-mediated unfolded protein response activity versus CSNK1G2 in STOMACH (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CSNK1G2 →	-1.143	-0.379	.003	.002	3	7
BLOOD_Leukemia	PTPN1 →	+0.758	+0.124	.001	.005	3	7
LIVER	CHMP4B →	+1.035	+0.394	<.001	.002	3	7
PANCREAS	DNAH5 →	+0.832	+0.288	<.001	<.001	3	6
LUNG_SCLC	PIGT →	+0.896	+0.305	.001	.001	3	6
LUNG_SCLC	MAPT →	-1.957	-0.226	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903898 vs CSNK1G2 — STOMACH

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