Negative regulation of PERK-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Negative regulation of PERK-mediated unfolded protein response pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN1, SGTA, and CDC37, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of PERK-mediated unfolded protein response activity versus PTPN1 in LUNG_NSCLC_LUSC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PTPN1 →	+2.229	+0.428	<.001	.003	3	18
STOMACH	SGTA →	-2.318	-0.422	<.001	<.001	3	17
STOMACH	CDC37 →	-1.812	-0.502	<.001	<.001	3	17
LUNG_NSCLC_LUSC	CACYBP →	-2.296	-0.286	<.001	.001	3	17
STOMACH	RPN2 →	+1.558	+0.362	<.001	<.001	3	17
STOMACH	NCLN →	+0.900	+0.316	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903898 vs PTPN1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →