Regulation of PERK-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the Regulation of PERK-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLL, SNX25P1, and KIF3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of PERK-mediated unfolded protein response activity versus POLL in COAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	POLL →	-0.277	-0.124	.003	.001	3	4
PDAC	SNX25P1 →	-0.440	-0.296	<.001	.005	3	4
CCRCC	KIF3B →	-0.273	-0.178	.002	.009	3	4
HNSC	CCDC90B →	-0.499	-0.124	.003	.006	3	3
HNSC	CCDC74B →	-0.306	-0.108	.008	.004	3	3
HNSC	BROX →	-0.511	-0.138	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903897 vs POLL — COAD

Explore this scatter interactively →