Regulation of PERK-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Regulation of PERK-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOSL1, IDH1, and RDH14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOSL1 grouped by Regulation of PERK-mediated unfolded protein response-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FOSL1 →	-1.823	-0.834	.003	<.001	3	5
LIVER	IDH1 →	-1.642	-1.345	<.001	.003	3	4
BONE	RDH14 →	-0.661	-0.456	.001	.001	3	4
KIDNEY	PPIE →	+0.938	+1.282	<.001	.001	3	3
LUNG_SCLC	AUTS2 →	+2.499	+0.245	.005	.004	2	4
LUNG_SCLC	S1PR5 →	-1.441	-0.322	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOSL1 by Regulation of PERK-mediated unfolded protein response activity — CNS

Explore this box plot interactively →