Regulation of PERK-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Regulation of PERK-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2O, KRT18, and ACSM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of PERK-mediated unfolded protein response activity versus UBE2O in SOFT_TISSUE (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	UBE2O →	-0.603	-0.363	.007	<.001	3	6
OVARY	KRT18 →	+3.275	+0.315	.003	<.001	3	6
OVARY	ACSM1 →	+0.340	+0.201	.003	.002	3	6
OVARY	KRT8 →	+3.252	+0.287	.001	<.001	3	6
BREAST	GPRIN1 →	-1.061	-0.277	.007	.001	2	7
PANCREAS	STARD9 →	-0.958	-0.381	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903897 vs UBE2O — SOFT_TISSUE

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