Positive regulation of IRE1-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the Positive regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DAB2IP, RPL10, and RSL1D1_S443, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of IRE1-mediated unfolded protein response activity versus DAB2IP in LSCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DAB2IP →	+0.280	+0.077	<.001	<.001	3	4
OV	RPL10 →	-0.377	-0.074	.003	<.001	3	4
BRCA	RSL1D1_S443 →	-0.752	-0.059	.001	<.001	3	4
BRCA	ASAH1 →	+0.350	+0.041	.005	.004	3	4
BRCA	RSL1D1 →	-0.479	-0.045	<.001	.001	3	4
BRCA	SMUG1 →	+0.278	+0.052	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903896 vs DAB2IP — LSCC

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