Positive regulation of IRE1-mediated unfolded protein response

Across TCGA patient cohorts, RNA activity of the Positive regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF660, MLH3, and RPAP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of IRE1-mediated unfolded protein response activity versus ZNF660 in PDAC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZNF660 →	-0.323	-0.222	.001	<.001	3	5
UCEC	MLH3 →	-0.331	-0.209	.008	.009	3	4
OV	RPAP3 →	-0.433	-0.126	.006	.009	3	4
BRCA	FYTTD1 →	-0.516	-0.196	.003	.004	3	4
OV	NKAPD1 →	-0.299	-0.145	.001	<.001	3	4
CCRCC	PPIAP20 →	-0.562	-0.154	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903896 vs ZNF660 — PDAC

Explore this scatter interactively →