Positive regulation of IRE1-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Positive regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN33, KIF26A, and FAM168B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of IRE1-mediated unfolded protein response activity versus TSPAN33 in PANCREAS (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TSPAN33 →	-1.751	-0.431	.002	<.001	3	4
LARGE_INTESTINE	KIF26A →	-1.349	-0.286	.003	<.001	3	4
LUNG_SCLC	FAM168B →	-0.757	-0.269	.004	.004	3	4
UPPER_AERODIGESTIVE_TRACT	ZFP69 →	-0.601	-0.343	.002	.002	3	4
PANCREAS	C1QL1 →	-0.865	-0.217	.007	.005	3	4
PANCREAS	CAPN1 →	+1.330	+0.332	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903896 vs TSPAN33 — PANCREAS

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