Regulation of IRE1-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EME1, MZT2A, and RGS9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EME1 grouped by Regulation of IRE1-mediated unfolded protein response-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EME1 →	+1.112	+0.238	.006	.003	3	3
PANCREAS	MZT2A →	+0.867	+0.240	.001	.007	3	3
SOFT_TISSUE	RGS9 →	+1.651	+0.364	<.001	<.001	3	3
SOFT_TISSUE	ISCA2 →	+0.690	+0.327	.004	.002	3	3
CNS	XRCC4 →	-0.477	-0.176	.003	.005	3	3
CNS	HAP1 →	+0.915	+0.190	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EME1 by Regulation of IRE1-mediated unfolded protein response activity — PANCREAS

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