Regulation of IRE1-mediated unfolded protein response

Across TCGA cell cohorts, RNA activity of the Regulation of IRE1-mediated unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRSK1, NFIL3, and KATNAL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of IRE1-mediated unfolded protein response activity versus BRSK1 in LUNG_NSCLC_LUAD (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BRSK1 →	-0.975	-0.113	.001	.001	3	6
BREAST	NFIL3 →	-1.208	-0.245	.004	.006	2	6
LUNG_NSCLC_LUAD	KATNAL1 →	-0.755	-0.135	.002	.003	3	5
SKIN	ANKRD40 →	-0.491	-0.167	<.001	<.001	3	5
OESOPHAGUS	PRELID3A →	-1.256	-0.174	.002	.002	3	5
BLOOD_Leukemia	ACAT2 →	-0.635	-0.120	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903894 vs BRSK1 — LUNG_NSCLC_LUAD

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