Extraembryonic membrane development

Across TCGA cell cohorts, RNA activity of the Extraembryonic membrane development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GABARAPL2, GCH1, and PKDCC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GABARAPL2 grouped by Extraembryonic membrane development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GABARAPL2 →	-0.654	-2.207	.001	.001	3	4
KIDNEY	GCH1 →	+1.191	+1.420	.005	.008	3	4
BLOOD_Leukemia	PKDCC →	-2.169	-1.194	.005	.001	3	4
SOFT_TISSUE	OAZ1 →	-0.738	-1.645	.001	.009	3	3
SOFT_TISSUE	AFF3 →	-1.555	-1.399	.005	.002	3	3
SOFT_TISSUE	NIPAL3 →	-1.263	-1.387	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GABARAPL2 by Extraembryonic membrane development activity — SOFT_TISSUE

Explore this box plot interactively →