Extraembryonic membrane development

Across TCGA cell cohorts, RNA activity of the Extraembryonic membrane development pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP22, PLEKHG1, and PREB, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP22 grouped by Extraembryonic membrane development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DUSP22 →	-0.195	-0.404	.005	.007	2	1
LARGE_INTESTINE	PLEKHG1 →	-0.115	-0.404	.009	.007	2	1
LARGE_INTESTINE	PREB →	-0.229	-0.404	<.001	.007	2	1
LARGE_INTESTINE	MBD5 →	-0.150	-0.404	.004	.007	2	1
LARGE_INTESTINE	UBA6 →	-0.274	-0.404	.008	.007	2	1
LARGE_INTESTINE	MEF2A →	-0.090	-0.404	.006	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP22 by Extraembryonic membrane development activity — LARGE_INTESTINE

Explore this box plot interactively →