Extraembryonic membrane development

Across TCGA cell cohorts, RNA activity of the Extraembryonic membrane development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BEND6, RASA2, and YEATS2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extraembryonic membrane development activity versus BEND6 in LARGE_INTESTINE (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BEND6 →	-0.190	-0.404	.002	.007	2	1
LARGE_INTESTINE	RASA2 →	-0.444	-0.404	.005	.007	2	1
LARGE_INTESTINE	YEATS2 →	-1.055	-0.404	.006	.007	2	1
LARGE_INTESTINE	TRIM68 →	-0.815	-0.404	.006	.007	2	1
LARGE_INTESTINE	ZNF160 →	-1.219	-0.404	.009	.007	2	1
LARGE_INTESTINE	ASCL2 →	-0.859	-0.404	.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903867 vs BEND6 — LARGE_INTESTINE

Explore this scatter interactively →