Regulation of dendrite extension

Across TCGA patient cohorts, RNA activity of the Regulation of dendrite extension pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CBX8, WIPF1_S276, and SPI1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendrite extension activity versus CBX8 in GBM (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CBX8 →	+0.466	+0.063	<.001	.001	3	7
GBM	WIPF1_S276 →	-0.475	-0.060	.001	.001	3	6
GBM	SPI1 →	-0.501	-0.072	<.001	<.001	3	5
COAD	TLN1 →	-0.411	-0.030	<.001	.002	3	5
BRCA	C2CD5 →	+0.265	+0.047	<.001	<.001	3	5
GBM	CAPZA1 →	-0.257	-0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903859 vs CBX8 — GBM

Explore this scatter interactively →