Regulation of dendrite extension

Across TCGA cell cohorts, RNA activity of the Regulation of dendrite extension pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC23A2, RIMS1, and U2AF1L4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC23A2 grouped by Regulation of dendrite extension-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC23A2 →	-0.282	-1.236	.001	<.001	2	8
LUNG_NSCLC_LUAD	RIMS1 →	-0.261	-0.741	<.001	.004	3	6
SOFT_TISSUE	U2AF1L4 →	-0.317	-1.510	.007	.001	3	5
LUNG_SCLC	ADCY2 →	-0.202	-1.048	.005	.008	3	5
SKIN	POM121L12 →	-0.153	-1.183	.003	<.001	3	5
LARGE_INTESTINE	MECP2 →	-0.247	-1.015	<.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC23A2 by Regulation of dendrite extension activity — CNS

Explore this box plot interactively →