Regulation of dendrite extension

Across TCGA cell cohorts, RNA activity of the Regulation of dendrite extension pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMBIM1, SERF1B, and ITGB8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendrite extension activity versus TMBIM1 in URINARY_TRACT (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMBIM1 →	-2.004	-0.408	<.001	.004	3	4
LUNG_SCLC	SERF1B →	+1.021	+0.913	.006	.007	3	4
SOFT_TISSUE	ITGB8 →	-1.988	-0.418	<.001	.003	3	4
BREAST	AVPI1 →	-1.037	-0.491	<.001	<.001	3	4
BREAST	ITGB4 →	-1.777	-0.380	.003	.009	3	4
LIVER	KDM4C →	+0.634	+0.434	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903859 vs TMBIM1 — URINARY_TRACT

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