Negative regulation of cellular response to transforming growth factor beta stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of cellular response to transforming growth factor beta stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTF3P3, ALMS1, and MYEF2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to transforming growth factor beta stimulus activity versus BTF3P3 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BTF3P3 →	+0.854	+0.201	.007	<.001	3	3
LSCC	ALMS1 →	-1.339	-0.157	.005	.001	3	2
LSCC	MYEF2 →	-1.483	-0.144	.001	<.001	3	2
LSCC	ALDH6A1 →	-0.937	-0.158	<.001	.001	3	2
LSCC	MDM2 →	-0.749	-0.148	.006	.001	3	2
BRCA	COG2 →	-0.909	-0.170	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903845 vs BTF3P3 — BRCA

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