Negative regulation of protein localization

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSME2, EPCAM, and RAB17, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSME2 grouped by Negative regulation of protein localization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PSME2 →	+0.927	+0.111	<.001	.004	3	6
LUNG_NSCLC_LUSC	EPCAM →	+5.314	+0.194	<.001	<.001	3	6
LUNG_NSCLC_LUAD	RAB17 →	+1.555	+0.101	.005	.006	3	5
BLOOD_Myeloma	IL11RA →	-2.070	-0.357	<.001	<.001	3	5
LUNG_NSCLC_LUSC	PPM1F →	-1.388	-0.164	.003	.001	3	5
LUNG_NSCLC_LUAD	TMEM62 →	+0.779	+0.127	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSME2 by Negative regulation of protein localization activity — BLOOD_Leukemia

Explore this box plot interactively →