Negative regulation of protein localization

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCM1, RPIA, and PRADC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization activity versus PCM1 in BONE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PCM1 →	+0.699	+0.295	.001	.005	3	6
OESOPHAGUS	RPIA →	+1.185	+0.209	.002	.008	2	6
SKIN	PRADC1 →	+0.650	+0.160	.005	.003	3	5
SKIN	M6PR →	+0.607	+0.143	<.001	<.001	3	5
OESOPHAGUS	TSPAN10 →	-1.027	-0.181	.003	.005	3	5
UPPER_AERODIGESTIVE_TRACT	PWP1 →	+0.828	+0.134	.004	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903828 vs PCM1 — BONE

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