L-arginine transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-arginine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABI3BP, FRZB, and SAMD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-arginine transmembrane transport activity versus ABI3BP in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABI3BP →	-0.781	-0.402	<.001	.006	3	4
GBM	FRZB →	-0.887	-0.466	.002	.004	3	4
BRCA	SAMD3 →	-0.524	-0.516	<.001	.004	3	4
BRCA	FUT4 →	-0.383	-0.603	.007	.001	3	4
HNSC	MAGI2-AS3 →	-0.451	-0.293	.004	.005	3	4
BRCA	FBLN5 →	-0.787	-0.507	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903826 vs ABI3BP — BRCA

Explore this scatter interactively →