L-arginine transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-arginine transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARPC5, SNX3, and STIM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-arginine transmembrane transport activity versus ARPC5 in BRCA (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARPC5 →	-0.348	-0.795	<.001	<.001	3	4
BRCA	SNX3 →	-0.254	-0.657	<.001	<.001	3	3
UCEC	STIM1 →	+0.629	+0.975	<.001	<.001	3	3
OV	EDC4_S879 →	-0.971	-0.754	<.001	<.001	3	3
BRCA	NCOA7_S179 →	-0.345	-0.440	.001	.008	3	3
BRCA	NECAP2 →	-0.299	-0.698	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903826 vs ARPC5 — BRCA

Explore this scatter interactively →