L-arginine transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-arginine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP5S1, EDEM1, and CTSL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AP5S1 grouped by L-arginine transmembrane transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AP5S1 →	-0.649	-1.212	.004	.002	3	4
BONE	EDEM1 →	-1.440	-1.268	.004	.009	3	4
SOFT_TISSUE	CTSL →	-1.200	-1.510	.009	<.001	3	3
SKIN	B3GALNT2 →	+0.480	+0.859	.002	.002	3	3
SKIN	ASNS →	+1.414	+1.021	.005	<.001	3	3
KIDNEY	PEX16 →	-0.528	-1.186	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AP5S1 by L-arginine transmembrane transport activity — OVARY

Explore this box plot interactively →