L-arginine transmembrane transport

Across TCGA cell cohorts, RNA activity of the L-arginine transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPP1, CACHD1, and TRIM7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-arginine transmembrane transport activity versus MPP1 in BONE (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MPP1 →	+1.639	+1.798	.001	.002	3	3
SKIN	CACHD1 →	-1.041	-0.422	.002	.009	2	4
OESOPHAGUS	TRIM7 →	+1.387	+1.202	<.001	.001	3	3
CNS	TLE4 →	+2.071	+1.685	.006	<.001	2	4
BONE	EFHD2 →	+2.610	+1.869	<.001	<.001	3	2
BONE	PDLIM3 →	+5.690	+1.869	.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903826 vs MPP1 — BONE

Explore this scatter interactively →