Negative regulation of voltage-gated potassium channel activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of voltage-gated potassium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, MFSD4A, and ARL4AP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of voltage-gated potassium channel activity activity versus ANK3 in CCRCC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANK3 →	+1.601	+1.259	<.001	<.001	3	10
GBM	MFSD4A →	+0.769	+0.501	<.001	<.001	3	7
CCRCC	ARL4AP1 →	+1.035	+1.071	<.001	<.001	3	6
PDAC	ATP13A4 →	+0.823	+0.639	<.001	<.001	3	5
GBM	CDKL2 →	+0.844	+0.560	<.001	<.001	3	5
GBM	PAIP2B →	+1.492	+0.673	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903817 vs ANK3 — CCRCC

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