Negative regulation of voltage-gated potassium channel activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of voltage-gated potassium channel activity pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C11orf45, CAB39, and MYBL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C11orf45 grouped by Negative regulation of voltage-gated potassium channel activity-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C11orf45 →	+0.353	+1.423	<.001	<.001	3	5
OESOPHAGUS	CAB39 →	+0.268	+1.216	<.001	.005	3	5
LUNG_NSCLC_LUSC	MYBL2 →	+0.617	+1.705	<.001	<.001	3	5
LUNG_NSCLC_LUAD	IQGAP1 →	+0.209	+1.236	.001	<.001	3	5
BLOOD_Leukemia	DELEC1 →	-0.254	-1.334	.005	<.001	3	5
LUNG_NSCLC_LUSC	GALK1 →	+0.241	+1.327	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C11orf45 by Negative regulation of voltage-gated potassium channel activity activity — BLOOD_Leukemia

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