Glycine import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Glycine import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCN3, CBX8, and FAP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycine import across plasma membrane activity versus RCN3 in BRCA (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RCN3 →	+0.574	+0.120	<.001	<.001	3	6
GBM	CBX8 →	-0.583	-0.168	<.001	<.001	3	6
OV	FAP →	+0.816	+0.076	.003	.001	3	6
OV	PPP1R18_S368 →	+0.911	+0.085	<.001	<.001	3	6
CCRCC	MAP7D1_S70 →	+0.530	+0.098	.001	.003	3	6
UCEC	PALLD_S669 →	+0.828	+0.082	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903804 vs RCN3 — BRCA

Explore this scatter interactively →