Glycine import across plasma membrane

pathway activity — cross-omics
GO:1903804Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Glycine import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7D1, OR10D1P, and RNY1P11, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAMAP7D1 →+0.911+0.102.001.00622
BRCAOR10D1P →+0.310+0.094.002.00131
BRCARNY1P11 →+1.655+0.094<.001.00131
BRCASNORA38 →+2.320+0.094<.001.00131
BRCAAKAP17BP →+0.085+0.094<.001.00131
BRCACALM1P1 →+0.480+0.098<.001.00231
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration