Glycine import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Glycine import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNG1, SLCO4A1, and NECTIN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCNG1 grouped by Glycine import across plasma membrane-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCNG1 →	-1.155	-1.113	.003	.004	3	4
STOMACH	SLCO4A1 →	+1.971	+1.477	.004	<.001	3	3
LUNG_NSCLC_LUSC	NECTIN1 →	+2.373	+1.269	.004	.002	3	3
LUNG_NSCLC_LUSC	AP2A2 →	-1.160	-1.404	<.001	.006	3	3
STOMACH	B3GNT2 →	+1.375	+1.644	<.001	<.001	3	3
SKIN	RHOV →	+0.336	+0.861	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCNG1 by Glycine import across plasma membrane activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →