L-glutamine import across plasma membrane

Across TCGA cell cohorts, RNA activity of the L-glutamine import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC44A2, OXSR1, and TJP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC44A2 grouped by L-glutamine import across plasma membrane-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC44A2 →	-0.928	-1.026	.007	<.001	3	5
LUNG_NSCLC_LUAD	OXSR1 →	-0.805	-0.895	<.001	.009	3	4
BREAST	TJP1 →	-0.867	-0.957	<.001	.001	3	4
OVARY	ZNF333 →	+1.050	+1.200	<.001	<.001	3	4
BLOOD_Leukemia	CCSER2 →	-0.920	-1.148	.004	.001	3	4
SKIN	AIDA →	-0.660	-1.141	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC44A2 by L-glutamine import across plasma membrane activity — SKIN

Explore this box plot interactively →